Nikolau Syndrome: Necrotic Activity of Drugs and Ways to Prevent Post-Injection Abscesses (In memory of Professor László A Gömze)

Post-injection abscess, which is the sad finale of Nicolau syndrome, continues to attract attention researchers due need clarify causes this iatrogenic disease in order develop effective measures for its prevention. For many years, from all over world have tried different perspectives explain mechanism drugs effect that post-injection pain infiltration, inflammation, erimatous skin damage, necrosis and abscess (Nicolau syndrome), but no avail. This has been done only recent years. There are findings Russia show considered be high quality today, some cases, addition specific pharmacological activity, may necrotic activity a non-specific nature action. The showed according established pharmaceutical practice full compliance with pharmacopoeia requirements medicines, products produced by companies, as well those included series same company, compositions (formulations), contain ingredients, therefore they physico-chemical properties. In regard, serial numbers and/or manufacturers, high-quality can hypertonic solutions, acidifying or alkalizing alcohols, aldehydes heavy metal salts denaturing concentrations. reason cases (cauterizing) activity. prevent it proposed reduce aggressiveness drugs. Today, successfully diluting them water injection 2 8 times before injection.